On April 22, 1950 Peter Kenneth Frampton was born to Owen and Peggy Frampton in Beckenham, Kent, UK

At the age of 10, Peter played in a band called The Little Ravens. He and David Bowie both went to Bromley Technical School and would spend lunch breaks together, playing Buddy Holly songs. The Little Ravens and Bowie's band, George and the Dragons, played shows together. When he was 11 years old, he played in the Trubeats before joining The Preachers, a band that Rolling Stones bassist Bill Wyman produced and managed.

Peter became a successful child guitarist, and in 1966 he became a member of The Herd, landing three British Top 10 hits. He was also named The Face of 1968 by Rave, a teen magazine.

In 1969, when Peter was 18 years old in 1969, he co-founded one of the first super groups, seminal rock act Humble Pie with Steve Marriott.

Peter met Pete Drake in 1970, on George Harrison’s session for his All Things Must Pass album.  Pete introduced Peter to the "talk box" which would become one of Frampton's trademark guitar effects. In 1972, Peter's solo career debut Wind of Change was released, with guest artists Billy Preston and Ringo Starr.

Peter released a whopping 6 albums in this decade: Frampton's Camel was released in 1973 and Somethin's Happening was released in 1974. In 1975, Frampton was released and rose to #32 in the US charts, and was certified Gold by the RIAA. In 1976, Frampton Comes Alive! was released and became a best-selling live album with hit singles "Baby, I Love Your Way," "Show Me the Way," and "Do You Feel Like We Do". In 1977, I'm In You was released and went platinum

In 1978, Peter starred in Sgt. Pepper's Lonely Hearts Club Band with The Bee Gees, Aerosmith, Billy Preston, George Burns and others. Later that year, Peter was in a near-fatal car accident in the Bahamas.

Peter received a star on the Hollywood Walk of Fame in 1979 and that same year, Where I Should Be was released.

Rise Up was released in 1980. The same year, Peter's black Les Paul Custom, "Phenix", was lost in a plane crash. In 1981, Breaking All the Rules was released and was recorded almost completely live. 1982 brought the release of The Art of Control. In 1986, Premonition was released with the hit single, "Lying". Frampton played on David Bowie's album Never Let Me Down in 1987 and joined Bowie on his Glass Spider tour.

In 1994, the Peter Frampton album was released. Frampton Comes Alive! II was recorded on June 15, 1995 at The Fillmore Theater in San Francisco. In 1996, Peter appeared as himself on the hit tv show The Simpsons headlining Homerpalooza.

In 2000, Peter was the technical advisor for Cameron Crowe’s Oscar winning movie, Almost Famous. Peter wrote a lot of the music on the soundtrack and appeared in the film as Humble Pie’s road manager. The album Now was released in 2003 and Frampton embarked on a tour with Styx. In 2006, Peter released the album Fingerprints. And in 2007, the album won a Grammy Award for Best Pop Instrumental Album. Peter was immortalized as himself on The Family Guy in 2009.

Thank You Mr Churchill was released in 2010 and was Peter's 14th studio album. The album included a song written with his son, Julian Frampton. Peter went on a North American tour with the band Yes. 2011 marked the 35th anniversary of Frampton Comes Alive! and Peter embarked on a 69 date tour playing the songs exactly as they were recorded on the album. In 2012, Peter received ASCAP’s Global Impact Award. In 2013, Frampton's Guitar Circus went on tour featuring guest performers B.B. King, Robert Cray, Don Felder, Rick Derringer, Kenny Wayne Shepherd, Steve Lukather, Sonny Landreth, Davy Knowles, David Hidalgo, Mike McCready, Roger McGuinn and Vinnie Moore. Frampton was one of several musicians to participate in 2014's The Night That Changed America: A Grammy Salute to The Beatles tribute to the Beatles on the 50th anniversary of their first appearance on American television. Hummingbird in a Box was released in 2014 and Peter performed a few shows live onstage with the Cincinnati Ballet. Acoustic Classics was released in 2015, featuring many of his hits. In 2016, Frampton was inducted into the Musicians Hall of Fame and Museum. Peter toured with the Steve Miller Band in 2017 and 2018 and was given the Les Paul Innovation Award at NAMM in 2018 as well.

On February 22, 2019 Frampton announced his retirement from rigorous touring with his 'Peter Frampton Finale—The Farewell Tour' after disclosing his diagnosis of inclusion body myositis (IBM), a progressive muscle disorder. That same year, Peter was honored at The Music Business Association Awards & Hall Of Fame Dinner with the Chairman’s Award For Sustained Creative Achievement. Also in 2019, All Blues was released and debuted at number one and stayed there for 15 weeks on the Billboard Top Blues Albums Chart.

In 2020 Frampton published his memoir, Do You Feel Like I Do?, co-written with Alan Light that debuted on the New York Times Best Seller List. Also, in 2020, Frampton Comes Alive! was inducted in to the Grammy Hall of Fame. Frampton Forgets the Words album released in 2021.